Zhang Research Group: Biomaterials and Nanomedicines

 

School of Chemical Engineering and Technology,

 

Key laboratory of Systems Bioengineering (MOE),

Tianjin University, Tianjin, P. R. China

 

 

部分成果:

 

Yumiao Zhang, Mansik Jeon, Laurie J. Rich, Hao Hong, Jumin Geng, Yin Zhang, Sixiang Shi, Todd E. Barnhart, Paschalis Alexandridis, Jan D. Huizinga, Mukund Seshadri, Weibo Cai, Chulhong Kim & Jonathan F. Lovell*.

Non-invasive Multimodal Functional Imaging of the Intestine with Frozen Micellar Naphthalocyanines (pdf)(SI)(video1)(video2)

Nature Nanotechnology, 2014, 9, 631-639

 

 

Yumiao Zhang#, Wentao Song#, Jumin Geng, Upendra Chitgupi, Hande Unsal, Jasmin Federizon, Javid Rzayev, Dinesh K. Sukumaran, Paschalis Alexandridis & Jonathan F. Lovell*.

Therapeutic Surfactant-stripped Frozen Micelles (pdf)

Nature Communications, 2016, 7, 11649

 

 

Yumiao Zhang, Depeng Wang, Shreya Goel, Boyang Sun, Upendra Chitgupi, Jumin Geng, Haiyan Sun, Todd E. Barnhart, Weibo Cai, Jun Xia, Jonathan F. Lovell*.

Surfactant stripped Frozen Pheophytin Micelles for Multimodal Gut Imaging (pdf)

Advanced Materials, 2016,28, 8524-8530

 

 

Jiexin Li, He Ren, Qian Qiu, Xingyue Yang, Jingyu Zhang, Chen Zhang, Boyang Sun, Jonathan F. Lovell, Yumiao Zhang*.

Manganese coordination micelles that activate stimulator of interferon genes and capture in-situ tumor antigens for cancer metalloimmunotherapy (pdf)

ACS Nano, 2022, 16, 10, 16909-16923 

 

 

Jiexin Li, Qian Qiu, He Ren, Jingyu Zhang, Chen Zhang, Gengqi Liu, Boyang Sun, Bin Zheng, Jonathan F Lovell, Yumiao Zhang*.

A metalloprotein nanoparticle scaffold co-delivers antigens and adjuvants with metal-enhanced STING activation for vaccination preventing viral infections (pdf)

Nano Today, 2024, 10215.

 

 

Boyang Sun, Georgios Paraskevopoulos, Jiwei Min, Robert Rossdeutcher, Sanjana Ghosh, Breandan Quinn, Meng-Hsuan Lin, Debanjan Sarkar, Dinesh Sukumaran, Yuefei Wang*, Kateřina Vávrová*, Jonathan F Lovell*, Yumiao Zhang*.

Topical Drug Delivery of Concentrated Cabazitaxel in an α-Tocopherol and DMSO Solution (pdf)

Advanced Science, 2023, Aug 9:e2302658

 

 

Jiexin Li, He Ren, Yumiao Zhang*.

Metal-based nano-vaccines for cancer immunotherapy (pdf)

Coordination Chemistry Reviews, 2022, 455, 214345

 

 

He Ren#, Jiexin Li# , Jonathan F. Lovell*, Yumiao Zhang*.

Organic coordination nanoparticles for phototheranostics (pdf)

Coordination Chemistry Reviews, 2024, 503, 215634

  

 

 

 

全部列表:

 

 

2024

 

 

 

Jiexin Li,  Ruiqi Yang, Fuqiang Dong, Qian Qiu, Zhen Jiang, Chen Zhang, Gengqi Liu, Jonathan F. Lovell, Yumiao Zhang*.

Enzyme-Dynamic Extracellular Vesicles for Metalloimmunotherapy of Malignant Pleural Effusions (pdf)

ACS Nano, 2024 18 (33), 21855-21872

 

 

Zixuan Wang#, Jiaxing Zhang#, Yuefei Wang*, Jialin Zhou, Xinhao Jiao, Mingshan Han, Xuelin Zhang, Hailiang Hu, Rongxin Su, Yumiao Zhang, Wei Qi

Overcoming Endosomal Escape Barriers in Gene Drug Delivery Using De Novo Designed pH-Responsive Peptides (pdf)

ACS Nano, 2024, 18, 10324-10340

 

 

Qian Qiu, Jiexin Li, He Ren, Jingyu Zhang, Gengqi Liu, Boyang Sun, Chen Zhang, Yumiao Zhang*.

Zinc Coordination Lipid Nanoparticles Co-Delivering Calcium Peroxide and Chelating STING agonist for Enhanced Cancer Metalloimmunotherapy (pdf)

Small, 2024, 2402308

 

 

He Ren#, Zewen Wu#, Jingxuan Li, Nan Zhang, Coo Yee Nah, Jiexin Li, Jingyu Zhang, Jonathan F. Lovell, Liyun Zhang*, Yumiao Zhang*.

A biomimetic, triggered-release micelle formulation of methotrexate and celastrol controls collagen-induced arthritis in mice (pdf)

BMEMat, 2024, e12104

 

 

He Ren#, Minchao Hao#, Gengqi Liu, Jiexin Li, Zhen Jiang, Wenlu Meng, Yumiao Zhang*.

Oxygen Self-Supplied Perfluorocarbon-Modified Micelles for Enhanced Cancer Photodynamic Therapy and Ferroptosis (pdf)

ACS Applied Bio Materials, 2024 7(5), 3306-3315

 

 

Jingyu Zhang, Jonathan F Lovell, Jiafu Shi*, Yumiao Zhang*.

Nanomaterials for co-immobilization of multiple enzymes (pdf)

BMEMat, 2024, e12080

 

 

Gengqi Liu, Jiexin Li, Xiaojie Wang, Ren He, Yumiao Zhang*.

An Activatable Dual Polymer Nanosystem for Photoimmunotherapy And Metabolic Modulation of Deep-Seated Tumors (pdf)

Advanced Healthcare Materials, 2024, 202303305

 

 

Jiexin Li, Qian Qiu, He Ren, Jingyu Zhang, Chen Zhang, Gengqi Liu, Boyang Sun, Bin Zheng, Jonathan F Lovell, Yumiao Zhang*.

A metalloprotein nanoparticle scaffold co-delivers antigens and adjuvants with metal-enhanced STING activation for vaccination preventing viral infections (pdf)

Nano Today, 2024, 10215.

 

 

He Ren#, Jiexin Li# , Jonathan F. Lovell*, Yumiao Zhang*.

Organic coordination nanoparticles for phototheranostics (pdf)

Coordination Chemistry Reviews, 2024, 503, 215634

 

 

2023

 

 

 

Jingang Liu, He Ren, Chen Zhang, Jiexin Li, Qian Qiu, Nan Zhang, Ning Jiang,Jonathan F. Lovell, and Yumiao Zhang*.

Orally-delivered, Cytokine-engineered Extracellular Vesicles for Targeted Treatment of Inflammatory Bowel Disease (pdf)

Small, 2023, 2304023

 

 

Boyang Sun, Georgios Paraskevopoulos, Jiwei Min, Robert Rossdeutcher, Sanjana Ghosh, Breandan Quinn, Meng-Hsuan Lin, Debanjan Sarkar, Dinesh Sukumaran, Yuefei Wang*, Kateřina Vávrová*, Jonathan F Lovell*, Yumiao Zhang*.

Topical Drug Delivery of Concentrated Cabazitaxel in an α-Tocopherol and DMSO Solution (pdf)

Advanced Science, 2023, Aug 9:e2302658

 

 

He Ren, Jiexin Li, Jingyu Zhang, Jingang Liu, Xingyue Yang, Nan Zhang, Qian Qiu, Dan Li, Yue Yu, Xiaofeng Liu, Jonathan F. Lovell, Yumiao Zhang*.

Anti-tumor immunity induced by a ternary membrane system derived from cancer cells, dendritic cells and bacteria (pdf)

Small, 2023, 2002756

 

        Selected as back cover feature

 

 

Boyang Sun#, Jingang Liu#, Silu Li, Jonathan F. Lovell* ,and Yumiao Zhang*.

Imaging of Gastrointestinal Tract Ailments (pdf)
Journal of Imaging, 2023, 9, 115

 

 

Chen Zhang, Xiaojie Wang, Gengqi Liu, He Ren, Zhen Jiang, Jingang Liu, Jonathan F. Lovell, Yumiao Zhang*.

Metal Coordination Micelles for Anti-cancer Treatment by Gene-editing and Phototherapy (pdf)

Journal of Controlled Release, 2023, 356, 210-221

 

 

Chen Zhang, Xiaojie Wang, Gengqi Liu, He Ren, Jingang Liu, Zhen Jiang, Yumiao Zhang*.

CRISPR/Cas9 and Chlorophyll Coordination Micelles for Cancer Treatment by Genome Editing and Photodynamic Therapy (pdf)

Small, 2023, 19, 2206981

 

 

Boyang Sun, Shuai Shao*, Sanjana Ghosh, Jiexin Li, Xiaojie Wang, Changning Li, Breandan Quinn, Paschalis Alexandridis, Jonathan F. Lovell*, Yumiao Zhang*.

Facile Preparation of Cabazitaxel-Loaded Nanoparticles Directly Lyophilized from Dioxane (pdf)

Science China Materials, 2023, 66(6): 2513-2522

 

 

Xingyue Yang, He Ren, Jiexin Li, Boyang Sun, Di Lu, Shuying Li, Yumiao Zhang*.

Multifunctional ZnFeO4-Based Antibiotic-Crosslinked Nanoplatform for Magnetically-Targeted Treatment of Microbial Biofilms (pdf)

ACS Applied Nano Materials, 2023, 6, 2141-2150

  

 

2022

 

 

 

  

Zhen Jiang#, Yuanmeng Ding#, Jonathan F. Lovell, Yumiao Zhang*.

Design and application of organic contrast agents for molecular imaging in the second near infrared (NIR-II) window (pdf)

Photoacoustics, 2022, https://doi.org/10.1016/j.pacs.2022.100426

 

 

Jiexin Li, He Ren, Qian Qiu, Xingyue Yang, Jingyu Zhang, Chen Zhang, Boyang Sun, Jonathan F. Lovell, Yumiao Zhang*.

Manganese coordination micelles that activate stimulator of interferon genes and capture in-situ tumor antigens for cancer metalloimmunotherapy (pdf)

ACS Nano, 2022, 16, 10, 16909-16923 

 

 

Qian Qiu, Di Lu, Gengqi Liu, Xingyue Yang, Jiexin Li, He Ren, Jingang Liu, Boyang Sun, Yumiao Zhang* .

Colistin Crosslinked gemcitabine micelles to eliminate tumor drug resistance caused by intratumoral microorganisms (pdf)

Bioconjugate Chemistry, 2022, 33, 10, 1944-1952

 

 

Boyang Sun, Jonathan F. Lovell, Yumiao Zhang*.

Current development of cabazitaxel drug delivery systems (pdf)

WIREs: Nanomedicine and Nanobiotechnology, 2022, http://doi.org/10.1002/wnan.1854

 

 

Boyang Sun, Sanjana Ghosh, Xuedan He, Wei-Chiao Huang, Breandan Quinn, Meiling Tian, Dushyant Jahagirdar, Moustafa T. Mabrouk, Joaquin Ortega, Yumiao Zhang*, Shuai Shao*, Jonathan F. Lovell*.

Anti-cancer liposmal chemophototherapy using bilayer-localized photosensitizer and cabazitaxel (pdf)

Nano Research, 2022, 15, 4302-4309

 

 

Gengqi Liu, Di Lu,  Shiyu Zhu, Minchao Hao, Xingyue Yang, Xiaojian Wang, Yumiao Zhang*.

A new self-immolative colistin prodrug with dual targeting functionalities and reduced toxicity for the treatment of intracellular bacterial infections (pdf)

Journal of Biomedical Materials Research A, 2022, 110, 1590-1598

     

 

Chen Zhang, He Ren, Gengqi Liu, Jiexin Li, Xiaojie Wang, Yumiao Zhang*.

Effective Genome Editing Using CRISPR-Cas9 Nanoflowers (pdf)

Advanced Healthcare Materials, 2022, 11, 10, 2102365 

 

 

He Ren, Jiexin Li, Gengqi Liu, Yaping Sun, Xingyue Yang, Zhen Jiang, Jingyu Zhang, Jonathan F Lovell, Yumiao Zhang*.

Anti-cancer vaccination with immunogenic micelles that capture and release pristine CD8+ T-Cell epitopes and adjuvants (pdf)

ACS Applied Materials & Interfaces, 2022, 14, 2, 2510-2521

 

 

Xingyue Yang, Qian Qiu, Gengqi Liu, He Ren, Xiaojie Wang, Jonathan F. Lovell, Yumiao Zhang*.

Traceless antibiotic-crosslinked micelles for rapid clearance of intracellular bacteria (pdf)

Journal of Controlled Release, 2022, 341, 329-340

 

 

Jiexin Li, He Ren, Yumiao Zhang*.

Metal-based nano-vaccines for cancer immunotherapy (pdf)

Coordination Chemistry Reviews, 2022, 455, 214345

 

 

Yuanmeng Ding#, Byullee Park#, Jiamin Ye#, Xiaojie Wang, Gengqi Liu, Xingyue Yang, Zhen Jiang, Moongyu Han, Yong Fan, Jibin Song*, Chulhong Kim*, Yumiao Zhang*.

Surfactant-stripped semiconducting polymer micelles for tumor theranostics and deep tissue imaging in the NIR-II window (pdf)

Small, 2022, 18, 2104132

 

 

2021

 

 

 

Jiexin Li, He Ren, Yaping Sun, Gengqi Liu, Xingyue Yang, Qian Qiu, Yuanmeng Ding, Jonathan F. Lovell, Yumiao Zhang*.

Magnetic metal micelles for enhanced delivery of self-immolating CD8+ T-cell epitopes for cancer immunotherapy (pdf)

Chemistry of Materials, 2021, 33, 24, 9780-9794

 

 

Zhen Jiang, Boyang Sun, Yueqi Wang, Heqi Gao, He Ren, Hao Zhang, Tong Lu, Xiangkui Ren, Wei Wei, Xiaoli Wang, Lei Zhang, Jiao Li, Dan Ding, Jonathan F. Lovell, Yumiao Zhang*.

Surfactant-stripped Micelles with Aggregation-induced Enhanced Emission for Bimodal Gut Imaging in vivo and Microbiota Tagging ex vivo (pdf)

Advanced Healthcare Materials, 2021, 10, 2100356

 

  

Gengqi Liu, Zhen Jiang, Jonathan F. Lovell,  Lei Zhang, Yumiao Zhang*.

Design of a Thiol-Responsive, Traceless Prodrug with Rapid Self-Immolation for Cancer Chemotherapy (pdf) (SI)

ACS Applied Bio Materials, 2021, 4, 6, 4982-4989.

  

 

Xingyue Yang, He Ren, Hong Zhang, Gengqi Liu, Zhen Jiang, Qian Qiu, Cui Yu, Niren Murthy, Kun Zhao*, Jonathan F Lovell*, Yumiao Zhang*.

Antibiotic-Crosslinked Micelles with Reduced Toxicity for Multidrug Resistant Bacterial Sepsis Treatment (pdf)

ACS Applied Materials & Interfaces, 2021, 13, 8, 9630-9642.

 

 

2020

 

 

 

Gengqi Liu, Jonathan F. Lovell, Lei Zhang*, Yumiao Zhang*.

Stimulus-Responsive Nanomedicines for Disease Diagnosis and Treatment (pdf

International Journal of Molecular Science, 2020, 21 (17), 6380

 

 

Maomao He, Jie Li, Hesong Han, Clarissa Araujo Borges, Gabriel Neiman, Joachim Justad Røise, Piotr Hadaczek, Rima Mendonsa, Victoria R. Holm, Ross C. Wilson, Krystof Bankiewicz, Yumiao Zhang, Corinne M. Sadlowski, Kevin Healy, Lee W. Riley  and  Niren Murthy*.

A traceless linker for aliphatic amines that rapidly and quantitatively fragments after reduction (pdf)

Chemical Science, 2020, 11, 8973-8980. 

 

 

Boyang Sun, Huang Jing, Moustafa T. Mabrouk, Yumiao Zhang, Honglin Jin*, Jonathan F. Lovell*.

A surfactant-stripped cabazitaxel micelle formulation optimized with accelerated storage stability (pdf)

Pharmaceutical Development and Technology, 2020, 25 (10) 1281-1288.

 

 

Xingyue Yang, Jonathan F. Lovell, Niren Murthy, Yumiao Zhang*

Organic Fluorescent Probes for Diagnostics and Bio-Imaging

Topics in Medicinal Chemistry (Book chapter)

 

 

2019

 

 

 

Boyang Sun, Upendra Chitgupi, Changning Li, Jasmin Federizon, Changjie Zhang, Donna M. Ruszaj, Aida Razi, Joaquin Ortega, Sriram Neelamegham, Yumiao Zhang, Jonathan F Lovell*. 

Surfactant-stripped cabazitaxel micelles stabilized by clotrimazole or mifepristone (pdf)

Advanced Therapeutics, 2019, 1900161.

 

 

Jing Yang, Chiyu Wen, Chao Pan, Hongshuang Guo, Weiqiang Zhao, Jiamin Zhang, Yingnan Zhu, Yumiao Zhang* & Lei Zhang*.

Nanoliposomal multi-drug delivery system with reduced toxicity and multi-drug resistance (pdf)

Journal of Materials Science, 2019, 54, 9718-9728.

 

 

Jiayin Song, Yingnan Zhu, Jiamin Zhang, Jing Yang, Yan Du, Weiwei Zheng, Chiyu Wen, Yumiao Zhang, Lei Zhang*.         

Encapsulation of AgNPs within zwitterionic hydrogel for highly efficient and antifouling catalysis in biological environments (pdf)

Langmuir, 2019, 35, 1563-1570

 

 

Dana Moukheiber, Upendra Chitgupi, Kevin A. Carter, Dandan Luo, Boyang Sun, Shreya Goel, Carolina A. Ferreira, Jonathan W. Engle, Depeng Wang, Jumin Geng, Yumiao Zhang, Jun Xia, Weibo Cai, and Jonathan F. Lovell*. 

Surfactant-Stripped Pheophytin Micelles for Multimodal Tumor Imaging and Photodynamic Therapy (pdf)

ACS Applied Bio Materials, 2019, 2, 544-554

 

 

2018

 

 

 

Xingyue Yang, Jonathan F. Lovell*, Yumiao Zhang*.

Ingestible contrast agents for gastrointestinal imaging (pdf)

ChemBioChem, 2018, 2, 462-473 

 

 

Yumiao Zhang, Joachim Justad Røise, Kunwoo Lee, Jie Li, Niren Murthy*. 

Recent developments in intracellular protein delivery (pdf)

Current Opinion  in Biotechnology, 2018, 52, 25-31

 

 

Jingtuo Zhang, Soo Jung Yang, Federico Gonzalez, Jiaying Yang, Yumiao Zhang, Maomao He, Nilabh Shastri and Niren Murthy*. 

A peptide-based fluorescent probe images ERAAP activity in cells and in high throughput assay (pdf)

Chemical Communications, 2018 ,54, 7215-7218 

 

 

2017

 

 

 

Yumiao Zhang, Hao Hong, Boyang Sun, Kevin Carter, Yiru Qin, Wei Wei, Depeng Wang, Mansik Jeon, Jumin Geng, Robert J. Nickles, Guanying Chen, Paras N. Prasad, Chulhong Kim, Jun Xia, Weibo Caif and Jonathan F. Lovell*.

Surfactant-stripped Naphthalocyanines for Multimodal Tumor Theranostics with Upconversion Guidance Cream (pdf)

Nanoscale, 2017, 9, 3391-3398

 

 

2016

 

 

 

Yumiao Zhang, Jonathan F. Lovell*. 

Recent Applications of Phthalocyanines and Naphthalocyanines for Imaging and Therapy (pdf)

WIREs: Nanomedicine and Nanobiotechnology, 2016,9, e1420

 

 

Jeesu Kim, Sara Park, Yuhan Jung, Sunyeob Chang, Jinyong Park, Yumiao Zhang, Jonathan F. Lovell* & Chulhong Kim*.

Programmable Real-time Clinical Photoacoustic and Ultrasound Imaging System (pdf)

Scientific Report, 6 (2016) 35137.

 

 

Yumiao Zhang, Depeng Wang, Shreya Goel, Boyang Sun, Upendra Chitgupi, Jumin Geng, Haiyan Sun, Todd E. Barnhart, Weibo Cai, Jun Xia, Jonathan F. Lovell*.

Surfactant stripped Frozen Pheophytin Micelles for Multimodal Gut Imaging (pdf)

Advanced Materials, 28 (2016) 8524-8530.

 

         Research comments in Nature Reviews Materials       

         Selected as back cover feature

         For other reports, click here

 

 

Yumiao Zhang#, Wentao Song#, Jumin Geng, Upendra Chitgupi, Hande Unsal, Jasmin Federizon, Javid Rzayev, Dinesh K. Sukumaran, Paschalis Alexandridis & Jonathan F. Lovell*.

Therapeutic Surfactant-stripped Frozen Micelles (pdf)

Nature Communications, 2016, 7, 11649

 

        Highlighted by Science Daily, EurekAlert! and Others 

 

 

Yang Zhou, Depeng Wang, Yumiao Zhang, Upendra Chitgupi, Jumin Geng, Yuehang Wang, Yuzhen Zhang, Timothy R Cook, Jun Xia, Jonathan F Lovell*.

 A Phosphorus Phthalocyanine Formulation with Absorbance of 1000 at 1000 nm for Deep Optical Imaging (pdf)

Theranostics, 2016, 6, 668-697

 

 

Yuehang Wang, Depeng Wang, Yumiao Zhang, Jumin Geng, Jonathan F Lovell, Jun Xia*.

Slit enabled Linear-array Photoacoustic Tomography with Near Isotropic Spatial Resolution in Three Dimensions (pdf)

Optics Letter, 2016, 41, 127-130 

 

 

2015

 

 

 

Yumiao Zhang, Jonathan F. Lovell*.

Reversible Micro- and Nano-Phase Programming of Anthraquinone Thermochromism Using Blended Block Copolymers (pdf)

Langmuir, 2015, 31, 13488-13493

 

 

Changho Lee, Jeesu Kim, Yumiao Zhang, Mansik Jeon, Chengbo Liu, Liang Song, Jonathan F. Lovell, Chulhong Kim*.

Dual-color photoacoustic lymph node imaging using nanoformulated naphthalocyanines (pdf)

Biomaterials, 2015, 73, 142-148 

 

 

Upendra Chitgupi, Yumiao Zhang, Chi Y Lo, Shuai Shao, Wentao Song, Jumin Geng, Sriram Neelamegham, Jonathan F Lovell*.

Sulfonated-polyethyleneimine for Photosensitizer Conjugation and Targeting (pdf)

Bioconjugate Chemistry, 2015, 26, 1633-1639

 

 

2014

 

 

 

Yumiao Zhang, Mansik Jeon, Laurie J. Rich, Hao Hong, Jumin Geng, Yin Zhang, Sixiang Shi, Todd E. Barnhart, Paschalis Alexandridis, Jan D. Huizinga, Mukund Seshadri, Weibo Cai, Chulhong Kim & Jonathan F. Lovell*.

Non-invasive Multimodal Functional Imaging of the Intestine with Frozen Micellar Naphthalocyanines (pdf)(SI)(video1)(video2)

Nature Nanotechnology, 2014, 9, 631-639

 

        Research comments in Nature Nanotechnology

        Research comments in Science Translational Medicine

        Highlight on NIH director's blog

 

 

2012

 

 

 

Yumiao Zhang, J. F. Lovell*.

Porphyrins as Theranostic Agents from Prehistoric to Modern Times (pdf)

Theranostics, 2012, 2, 905-916

         Selected as cover feature

 

 

2011

 

 

 

Junsong Chen#, Yumiao Zhang# (Co-first author), Xiongwen Lou*. (Postgraduate work in Singapore)

One-pot synthesis of uniform Fe3O4 nanospheres with carbon matrix support for improved lithium storage capabilities (pdf)

ACS Applied Materials & Interfaces, 2011, 3, 3276-3279. 

 

  

2010

 

 

 

Jingtao Wang, Yumiao Zhang, Hong Wu, Lulu Xiao, Zhongyi Jiang*.(Undergraduate work at Tianjin University) 

 Fabrication and performances of solid superacid embedded chitosan hybrid membranes for direct methanol fuel cell (pdf)

Journal of Power Sources, 2010, 195, 2526-2533